What should i do to delete a file thats been affected by a virus but runs up everytime window starts,cant del

Sounds like a tough one. If you have several viruses on your computer I recomend that you re-install Windows. This is the best way of clearing virus, junk etc. By doing this you delete your partitions where the virus may be residing. have you tried AVG I think that it is pretty good, not sure if it will do the trick but I do recommend that you re-install Windows